Nusantara Science and Technology Proceedings
by Future Science
openjournathemelogo
Quick jump to page content
  • Main Navigation
  • Main Content
  • Sidebar

Nusantara Science and Technology Proceedings
  • Current
  • Archives
  • Submissions
  • Announcements
  • About
    • Editorial Policies
    • Editorial Team
    • About the Journal
    • Publication Ethic
    • Privacy Statement
  • Contact
  • Register
  • Login
  • Current
  • Archives
  • Submissions
  • Announcements
  • About
    • Editorial Policies
    • Editorial Team
    • About the Journal
    • Publication Ethic
    • Privacy Statement
  • Contact
  1. Home
  2. Archives
  3. Join Proceeding "Basic and Applied Science Conference (BASC) 2021 & 1st Education Research and Applied Business Conference"
  4. Articles

Issue

Join Proceeding "Basic and Applied Science Conference (BASC) 2021 & 1st Education Research and Applied Business Conference"

Issue Published : Sep 6, 2021
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia

https://doi.org/10.11594/nstp.2021.1104
Harry Nugroho Eko Surniyantoro
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency
Nabilah Adzra Fahlevi
Faculty of Science and Applied Technology, Ahmad Dahlan University
Esa Savitri
Faculty of Science and Applied Technology, Ahmad Dahlan University
Tur Rahardjo
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency
Rita Maliza
Faculty of Science and Applied Technology, Ahmad Dahlan University
Ayu Rosemeilia Dewi
Nuclear Medicine, Dharmais Cancer Hospital
Yustia Tuti
Nuclear Medicine, Dharmais Cancer Hospital
Nastiti Rahajeng
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency
Yanti Lusiyanti
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency
Nur Rahmah Hidayati
Center for Technology of Radiation Safety and Metrology, National Nuclear Energy Agency

Corresponding Author(s) : Harry Nugroho Eko Surniyantoro

harry_nes@batan.go.id

Nusantara Science and Technology Proceedings, Join Proceeding "Basic and Applied Science Conference (BASC) 2021 & 1st Education Research and Applied Business Conference"
Article Published : Sep 6, 2021

Share
WA Share on Facebook Share on Twitter Pinterest Email Telegram
  • Abstract
  • Cite
  • References
  • Authors Details

Abstract

One of the important DNA repair pathways is base excision repair (BER), which plays in the human body to maintain DNA integrity, prevent cancer and DNA damage. X-ray repair cross-complementing group 1 (XRCC1) is the most important DNA repair protein in base excision repair (BER) pathways and has been reported to have a relationship with the risk of developing various cancers. The study was purposed to assess the genetic polymorphism of XRCC1 exon 6 and 10 as a risk factor for thyroid cancer. A total of 90 participants were enrolled in this study, consisted of 30 thyroid cancer patients as a case group and 60 non-cancer patients as a control group. Examination of XRCC1 genotypes was carried out by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method and statistical analysis using a Chi-square test. In this study, we reported the frequency of XRCC1 genetic polymorphism was not significantly different between cancer patients and control groups both in exon 6 and 10, and we predict that these polymorphisms were not a risk factor for thyroid cancer (P-value>0.05). In conclusion, both mutant variants of XRCC1 exon 6 and 10 are not risk factors for thyroid cancer.  In further studies, it is necessary to assess genetic polymorphisms in populations with controlled non-genetic factors, such as diet, lifestyle, and environmental factors.

Keywords

Base excision repair PCR-RFLP Thyroid cancer XRCC1 exon 6 and 10

Full Article

Generated from XML file
Surniyantoro, H. N. E. ., Fahlevi, N. A. ., Savitri, E. ., Rahardjo, T. ., Maliza, R. ., Dewi, A. R. ., Tuti, Y. ., Rahajeng, N. ., Lusiyanti, Y. ., & Hidayati, N. R. . (2021). Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia. Nusantara Science and Technology Proceedings, 21-26. https://doi.org/10.11594/nstp.2021.1104
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
Author biographies is not available.
Download this PDF file
PDF
Statistic
Read Counter : 89 Download : 115

Table Of Contents

NST Proceedings article template

Indexed By


 

 

 

Author Resources

  •    Author Guidelines
  •     Download Manuscript Template
  •   Review Process

Instagram Page

Keywords

Information

  • For Readers
  • For Authors
  • For Librarians

NST Proceeding

International Conference Partner

NST Proceedings is a journal that publishes articles produced from the results of conferences or similar events to the global research community to be easily accessed and approved by the conference committee.

ISSN : 2622-9692

 Address

Office: Perum Sarimadu II B3 No.09, Pakisaji,
Kab.Malang, Jawa Timur, Indonesia 65162

  Contact Info

Whatsapp: +62 812-3114-1854
editor.nst@futuresciencepress.com
This is work is licensed under  Creative Commons License
 a Creative Commons Attribution 4.0 International License.
Themes by Openjournaltheme.com
http://nstproceeding.com/index.php/nuscientechThemes by Openjournaltheme.com